Abstract | BACKGROUND: OBJECTIVE: DESIGN: Case-crossover design. SETTING: Nationwide study of Danish patients from 2000 to 2018. PATIENTS: Male patients with International Classification of Diseases, 10th Revision (ICD-10) codes for ischemic heart disease (IHD), including those who had a continuing prescription for nitrates and a new, filled prescription for PDE5 inhibitors. MEASUREMENTS: RESULTS: From 2000 to 2018, 249 541 male patients with IHD were identified. Of these, 42 073 patients had continuing prescriptions for nitrates. During this period, the prescription rate for PDE5 inhibitors in patients with IHD who were taking nitrates increased from an average of 0.9 prescriptions (95% CI, 0.5 to 1.2 prescriptions) per 100 persons per year in 2000 to 19.5 prescriptions (CI, 18.0 to 21.1 prescriptions) in 2018. No statistically significant association was found between the coprescription of nitrates with PDE5 inhibitors and the risk for either composite outcome (odds ratio [OR], 0.58 [CI, 0.28 to 1.13] for the first outcome and OR, 0.73 [CI, 0.40 to 1.32] for the second outcome). LIMITATION: An assumption was made that concurrently filled prescriptions for nitrates and PDE5 inhibitors equaled concomitant use. CONCLUSION: From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates. A statistically significant association between concomitant use of these medications and cardiovascular adverse events could not be identified. PRIMARY FUNDING SOURCE: Ib Mogens Kristiansens Almene Fond and Helsefonden.
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Authors | Anders Holt, Paul Blanche, Aksel Karl Georg Jensen, Nina Nouhravesh, Deepthi Rajan, Mads Hashiba Jensen, Mohammed El-Sheikh, Anne-Marie Schjerning, Morten Schou, Gunnar Gislason, Christian Torp-Pedersen, Patricia McGettigan, Morten Lamberts |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 175
Issue 6
Pg. 774-782
(06 2022)
ISSN: 1539-3704 [Electronic] United States |
PMID | 35436155
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitrates
- Phosphodiesterase 5 Inhibitors
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Topics |
- Cross-Over Studies
- Erectile Dysfunction
(chemically induced, drug therapy)
- Humans
- Male
- Myocardial Ischemia
(drug therapy)
- Nitrates
(adverse effects)
- Phosphodiesterase 5 Inhibitors
(adverse effects)
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