Captopril-induced lichen planus pemphigoides with pemphigus-like features. A case report.

Abstract

We report a case of a bullous lichenoid eruption due to the intake of captopril. Clinical, histological, direct immunofluorescence and ultrastructural features were consistent with the diagnosis of lichen planus pemphigoides. In addition, the in vivo immunological study also revealed an intercellular fluorescence, similar to that seen in pemphigus. Complex drug-induced cutaneous reactions have been previously reported with other drugs, especially with D-penicillamine, which bears chemical similarities with captopril. However, such a drug-induced mixed pattern of lichen planus pemphigoides with pemphigus-like features has never been reported.

• Authors: B Flageul, C Foldes, D Wallach, M D Vignon-Pennamen, F Cottenot
• Journal: Dermatologica (Dermatologica) Vol. 173 Issue 5 Pg. 248-55 ( 1986) ISSN: 0011-9075 [Print] Switzerland
• PMID: 3542612 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Captopril

Topics

• Autoantibodies (biosynthesis)
• Basement Membrane (immunology)
• Biopsy
• Captopril (adverse effects, therapeutic use)
• Extracellular Space (immunology)
• Fluorescent Antibody Technique
• Humans
• Hypertension (drug therapy)
• Lichen Planus (chemically induced, pathology)
• Male
• Middle Aged
• Pemphigus (chemically induced, pathology)
• Skin (pathology)