[Comparative evaluation of the anti-arrhythmia effectiveness of mezotrin and izoptin].

Abstract

Isoptin and mesotrin (a new hypothetical calcium antagonist) were administered to 30 patients with frequent and persistent premature beats (22 patients with premature ventricular beats and 8 patients with premature supraventricular beats). The antiarrhythmic activity of mesotrin was nearly twice as high as that of isoptin, the antiarrhythmic effect being achieved in 63 and 33% of patients, respectively, which was especially distinct in ventricular rhythm disturbances (64 and 27%, respectively). The effective dose of mesotrin was approximately 2.5 mg/kg. Isoptin produced the greatest effect on atrio-ventricular conduction, while mesotrin to a great extent influenced atrial and ventricular conduction. Certain side effects of mesotrin were observed, consisting in slight euphoria, ventigo and heavyheadedness subduing spontaneously 10-15 minutes after administering the drug. Care should be taken when administering the drug to patients with sick sinus syndrome because of the possibility of its arrest.

• Authors: E D Dzhishambaev, L A Ivanova, E M Bugriĭ, N A Mazur, T S Pavlova
• Journal: Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR (Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR) Vol. 9 Issue 2 Pg. 40-4 ( 1986) ISSN: 0201-7369 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia otsenka antiaritmicheskoĭ éffektivnosti mezotrina i izoptina.
• PMID: 3541963 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Diamines
• mesotrin
• Verapamil

Topics

• Adolescent
• Adult
• Anti-Arrhythmia Agents (adverse effects, pharmacology, therapeutic use)
• Arrhythmias, Cardiac (drug therapy, physiopathology)
• Clinical Trials as Topic
• Diamines (adverse effects, pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Electrocardiography
• Heart Rate (drug effects)
• Humans
• Middle Aged
• Monitoring, Physiologic
• Verapamil (adverse effects, pharmacology, therapeutic use)