Effects of chemical combinations on the induction of aneuploidy in Saccharomyces cerevisiae.

Abstract

Nocodazole, ethyl acetate, acetone and methyl ethyl ketone all are known to induce aneuploidy. Treatment of yeast strain D61.M with mixtures containing ineffective low levels of nocodazole and ineffective low levels of these solvents was highly effective in inducing aneuploidy. Ineffective low levels of nocodazole mixed with ineffective low levels of methyl 2-benzimidazolecarbamate also gave elevated frequencies of aneuploidy. Dimethyl formamide, a solvent that does not induce aneuploidy, mixed with low levels of nocodazole gave no increase in aneuploidy frequency above those levels seen in controls.

• Authors: V W Mayer, C J Goin
• Journal: Mutation research (Mutat Res) Vol. 187 Issue 1 Pg. 21-30 (Jan 1987) ISSN: 0027-5107 [Print] Netherlands
• PMID: 3540657 (Publication Type: Journal Article)

Chemical References

• Acetates
• Benzimidazoles
• Butanones
• Carbamates
• Mutagens
• Acetone
• methylethyl ketone
• ethyl acetate
• Dimethylformamide
• carbendazim
• Nocodazole
• Dimethyl Sulfoxide

Topics

• Acetates (pharmacology)
• Acetone (pharmacology)
• Aneuploidy
• Benzimidazoles (pharmacology)
• Butanones (pharmacology)
• Carbamates
• Dimethyl Sulfoxide (pharmacology)
• Dimethylformamide (pharmacology)
• Drug Synergism
• Mutagens (pharmacology)
• Nocodazole
• Saccharomyces cerevisiae (drug effects, genetics)