HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

An attempt to develop a model to study the effects of intrathecal steroids.

Abstract
An attempt has been made to develop a chronic inflammatory arachnoiditis model in the rat to study the influence of subarachnoid or epidural steroids. Through chronically implanted catheters in Wistar rats (250-350 g), either triamcinolone (3.5-350 micrograms) or methylprednisolone (3.5-350 micrograms) was injected intrathecally, daily for 7 days or weekly for 7 weeks. Some rats also received 100 mg kg-1 cefoxitin and 0.5 mg deoxycortone by intramuscular injection. Equivalent control groups were included. High doses of intrathecal steroids caused marked weight loss and infection and many rats died. These effects were mitigated at a lower dosage especially by the addition of cefoxitin and deoxycortone. The effects of triamcinolone were more marked than those of methylprednisolone. No systematic histological evidence of neurotoxicity was observed after either steroid. Injections of talc failed to cause arachnoiditis or meningitis probably because sufficient particulate talc could not be injected through the narrow catheter.
AuthorsE A Swai, M Rosen
JournalEuropean journal of anaesthesiology (Eur J Anaesthesiol) Vol. 3 Issue 2 Pg. 127-36 (Mar 1986) ISSN: 0265-0215 [Print] England
PMID3536491 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Desoxycorticosterone
  • Methylprednisolone Hemisuccinate
  • Cefoxitin
  • Triamcinolone Acetonide
  • triamcinolone hexacetonide
  • Methylprednisolone
Topics
  • Animals
  • Arachnoiditis (chemically induced)
  • Cefoxitin (administration & dosage)
  • Desoxycorticosterone (administration & dosage)
  • Disease Models, Animal
  • Drug Interactions
  • Injections, Spinal
  • Male
  • Meningitis (chemically induced)
  • Meningitis, Aseptic (chemically induced)
  • Methylprednisolone (analogs & derivatives)
  • Methylprednisolone Hemisuccinate (toxicity)
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord Diseases (chemically induced)
  • Triamcinolone Acetonide (analogs & derivatives, toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: