Uptake of platinum compounds in human tumors. In vitro study.

Abstract

The kinetics of intratumoral uptake of cisplatin, carboplatin (CBDCA) and TNO-6 were studied in vitro in fragments of tumors of the head and neck maintained in culture medium under conditions simulating therapeutic conditions of chemo-embolization. Cisplatin and TNO-6 are more rapidly taken up than CBDCA (carboplatin). With each of these compounds, after 24 hours a fraction of the platinum taken up is not irreversibly bound to the tissue. The rate of uptake and the proportion of platinum irreversibly bound depends a great deal on the tumor under study. The characteristics of the diffusion indicate that TNO-6 is better used with chemo-embolization than with systemic injection. The opposite finding is seen with carboplatin. Cisplatin appears to to be about equally well-suited for either method of injection.

• Authors: B Hecquet, A Leroy, J L Lefebvre, J P Peyrat, L Adenis
• Journal: Bulletin du cancer (Bull Cancer) Vol. 73 Issue 5 Pg. 535-41 ( 1986) ISSN: 0007-4551 [Print] France
• PMID: 3535936 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Platinum
• Carboplatin
• spiroplatin
• Cisplatin

Topics

• Aged
• Antineoplastic Agents (metabolism)
• Carboplatin
• Cells, Cultured
• Cisplatin (metabolism)
• Dose-Response Relationship, Drug
• Humans
• Laryngeal Neoplasms (metabolism)
• Male
• Middle Aged
• Mouth Neoplasms (metabolism)
• Organoplatinum Compounds (metabolism)
• Pharyngeal Neoplasms (metabolism)
• Platinum (metabolism)
• Time Factors