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Clotrimazole treatment for prevention of oral candidiasis in patients with acute leukemia undergoing chemotherapy. Results of a double-blind study.

Abstract
Fungal infections have become an increasing cause of morbidity in patients with acute leukemia undergoing chemotherapy. Oral candidiasis is prone to develop in these patients, and there is also a risk of the development of esophageal Candida infection. Clotrimazole troches have been previously reported to be effective in the treatment of documented oral Candida infection. This report documents a double-blind controlled study in 30 patients with acute leukemia in which the effectiveness of clotrimazole troches in preventing oropharyngeal candidiasis was assessed. Patients were randomly assigned to receive 10 mg troches of clotrimazole or a placebo three times per day. Mucosal scrapings were obtained weekly and examined directly by smear and culture. There were 28 evaluable patients. Of 12 patients with oral Candida infection, 11 were taking placebo and one received clotrimazole (p = 0.0002). Clotrimazole is effective in preventing oropharyngeal candidiasis.
AuthorsJ Cuttner, K M Troy, L Funaro, R Brenden, E J Bottone
JournalThe American journal of medicine (Am J Med) Vol. 81 Issue 5 Pg. 771-4 (Nov 1986) ISSN: 0002-9343 [Print] United States
PMID3535491 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Imidazoles
  • Clotrimazole
Topics
  • Acute Disease
  • Adult
  • Aged
  • Candidiasis, Oral (prevention & control)
  • Clinical Trials as Topic
  • Clotrimazole (therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Imidazoles (therapeutic use)
  • Leukemia (complications, drug therapy)
  • Male
  • Middle Aged
  • Random Allocation

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