HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

World-wide clinical experience with norfloxacin: efficacy and safety.

Abstract
This review covers 2346 norfloxacin treated patients in clinical trials world wide. These studies show that 400 mg of norfloxacin b.i.d. was effective and compared favorably with other standard oral agents in the treatment of urinary tract infections, including complicated and recurrent infections in men. This regimen given b.i.d. or t.i.d. was also effective in the treatment of acute gastroenteritis due to common gastrointestinal pathogens such as enterotoxigenic Escherichia coli, Salmonella spp., Shigella spp., Campylobacter spp. as well as less common organisms. A single 800 mg dose was effective in the treatment of gonorrhoea including patients with extra genito-urinary involvement and penicillinase producing strains of Neisseria gonorrhoeae. Preliminary data from ongoing trials have also shown that norfloxacin is effective in the prophylaxis of traveller's diarrhoea and infections in the granulocytopenic patient. These various regimens of norfloxacin were well tolerated with a low incidence (less than 3%) of drug related adverse experiences. The most common adverse experiences were nausea, headache, dizziness, rash, elevation of liver enzymes and eosinophilia.
AuthorsC Wang, J Sabbaj, M Corrado, V Hoagland
JournalScandinavian journal of infectious diseases. Supplementum (Scand J Infect Dis Suppl) Vol. 48 Pg. 81-9 ( 1986) ISSN: 0300-8878 [Print] England
PMID3535057 (Publication Type: Clinical Trial, Journal Article, Review)
Chemical References
  • Norfloxacin
Topics
  • Acute Disease
  • Agranulocytosis (complications)
  • Bacterial Infections (drug therapy)
  • Clinical Trials as Topic
  • Diarrhea (drug therapy)
  • Gastroenteritis (drug therapy)
  • Gonorrhea (drug therapy)
  • Humans
  • Norfloxacin (therapeutic use)
  • Recurrence
  • Travel
  • Urinary Tract Infections (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: