[Animal experiment and cell biology study of Saccharomyces cerevisiae Hansen CBS 5926 in the non-specific enhancement of resistance to infection].

Abstract

In an animal experimental study the effect of Saccharomyces cerevisiae (S.c.) Hansen CBS 5926 (Perenterol) on bacterial infections has been investigated using different forms of application. A significant protective effect after oronasal, intragastric and subcutaneous application of S.c. Hansen CBS 5926 has been found by challenge with Streptococcus pneumoniae and Escherichia coli. In order to investigate the possible mode of action the effect of S.c. Hansen CBS 5926 on chemiluminescence activity of polymorphonuclear cells from porcine blood has been studied. Isolated cells as well as cells in whole blood showed a significant induction of chemiluminescence. In comparison to Zymosan A the yeast cells originating from the commercial formulation showed a less pronounced ability to stimulate the chemiluminescence of blood cells. However, the stimulation was significantly enhanced after inactivation by heat.

• Authors: K Petzoldt, E Müller
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 7 Pg. 1085-8 (Jul 1986) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Tierexperimentelle und zellbiologische Untersuchungen zur Wirkung von Saccharomyces cerevisiae Hansen CBS 5926 bei der unspezifischen Steigerung der Infektionsabwehr.
• PMID: 3533083 (Publication Type: Journal Article)

Chemical References

• Zymosan

Topics

• Animals
• Bacterial Infections (immunology, prevention & control)
• Escherichia coli Infections (prevention & control)
• Female
• Immunity, Innate
• Immunization
• Luminescent Measurements
• Mice
• Pneumococcal Infections (prevention & control)
• Saccharomyces cerevisiae (immunology)
• Zymosan (therapeutic use)