HLA study of Japanese patients with Creutzfeldt-Jakob disease: significant association with HLA-DQw3.

Abstract

To demonstrate genetic susceptibility to Creutzfeldt-Jakob disease (CJD), 10 Japanese patients with pathologically proved CJD and 6 patients with clinically definite CJD were tissue typed for 48 class I and 14 class II human leukocyte antigen (HLA) specificities. The patients were scattered throughout Japan and there were no consanguineous relationships. Among 62 HLA specificities, HLA-DRw53 and DQw3 were found in all pathologically proved CJD cases. When the frequencies of the HLA antigens in the 16 CJD cases were compared to those of normal Japanese, a highly significant (p less than 0.005) increase was found for HLA-DQw3 in the CJD group. The present findings provide evidence for genetic control of susceptibility to CJD in humans.

• Authors: Y Kuroda, H Kaneoka, H Shibasaki, S Kume, M Yamaguchi
• Journal: Annals of neurology (Ann Neurol) Vol. 20 Issue 3 Pg. 356-9 (Sep 1986) ISSN: 0364-5134 [Print] United States
• PMID: 3532932 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-D Antigens
• HLA-DR Antigens

Topics

• Aged
• Brain (pathology)
• Creutzfeldt-Jakob Syndrome (genetics, pathology)
• Female
• HLA-D Antigens (analysis)
• HLA-DR Antigens (analysis)
• Humans
• Japan
• Male
• Middle Aged