Abstract |
Non-invasive pulmonary surfactant (SF) administration for neonatal respiratory distress syndrome (NRDS) is a development of administration of SF. Administration of SF via a supraglottic device (SGD) has been shown to be effective. Here the results of administration of SF in NRDS in infants requiring oxygen and nasal-CPAP (n-CPAP) via two types of SGDs, LMA® vs iGel®, in a second level Neonatal Unit are reported in a retrospective study. Results - Fourteen infants in the LMA®Group were matched with 21 comparable infants in the iGel® Group (g.a. ≥30 wks and b.w. ≥ 1,500 gr) presenting NRDS with fraction of inspired oxygen (FiO2) ≥ 0.25 - 0.6, requiring n-CPAP. All infants presented a significant improvement of PaO2/FiO2 ratio that was seen earlier in the iGel® Group vs the LMA® Group. There was no severe adverse effect during the maneuver with both SGDs. No baby died, No.2 required endotracheal intubation for a second dose of SF as by protocol, and No. 1 was transferred to a higher level of care. Conclusion - Non-invasive SF administration via SGD has been done effectively at a second level Neonatal Unit and very early in the course of the disease therefore limiting transfer of the baby without complications with both SGDs. Improvement in gas exchange was more rapid in the iGel®Group. This result needs confirmation. In our experience iGel® was easier to use than LMA®.
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Authors | Stefano Parmigiani, Giulio Bevilacqua |
Journal | Acta bio-medica : Atenei Parmensis
(Acta Biomed)
Vol. 93
Issue 1
Pg. e2022045
(03 14 2022)
ISSN: 2531-6745 [Electronic] Italy |
PMID | 35315413
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biological Products
- Phospholipids
- Pulmonary Surfactants
- Surface-Active Agents
- poractant alfa
- Oxygen
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Topics |
- Biological Products
- Humans
- Infant
- Infant, Newborn
- Oxygen
(therapeutic use)
- Phospholipids
(therapeutic use)
- Pulmonary Surfactants
(therapeutic use)
- Respiratory Distress Syndrome, Newborn
(therapy)
- Retrospective Studies
- Surface-Active Agents
(therapeutic use)
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