Dothiepin hydrochloride: treatment efficacy and safety.

Abstract

Dothiepin, a thio analogue of amitriptyline, has been used extensively in Europe during the past 15 years. It is a safe and effective agent for the treatment of major depressive disorder. Although the onset of action is comparable to that of other tricyclic antidepressants, dothiepin may cause fewer intolerable side effects and have less cardiotoxicity than these other compounds. In addition, dothiepin reduces the anxiety associated with some major depressive episodes. These features suggest that dothiepin may be particularly helpful for treating anxious depressed patients and patients who have underlying cardiac disease or who are elderly.

• Authors: P Zusky, T C Manschreck, C Blanchard, J Rosenbaum, C Elliot, P Lou
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 47 Issue 10 Pg. 504-7 (Oct 1986) ISSN: 0160-6689 [Print] United States
• PMID: 3531188 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Dibenzothiepins
• Dothiepin

Topics

• Adult
• Anxiety Disorders (drug therapy, psychology)
• Clinical Trials as Topic
• Constipation (chemically induced)
• Depressive Disorder (drug therapy, psychology)
• Dibenzothiepins (therapeutic use)
• Dothiepin (adverse effects, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Nausea (chemically induced)
• Psychiatric Status Rating Scales
• Sleep
• Xerostomia (chemically induced)