Abstract |
Since a water-soluble polysaccharide ( KGF-C) from the kefir grains was shown to have the property of retarding tumor growth in vivo when administered orally, the effect of KGF-C was examined on antibody responses to thymus-dependent antigen, sheep red blood cells (SRBC), and thymus-independent antigen, dinitrophenyl- Ficoll and trinitrophenyl-lipopolysaccharide. Antibody response in mice intubated with KGF-C was enhanced to low doses of SRBC, but not to optimal or high doses. The optimal dose of KGF-C required for the enhancement was 100 mg/kg body weight. The time-course studies on KGF-C administration implied that KGF-C exerted its effect on the early events of anti-SRBC response. The enhancement was not due to the alteration of kinetics of anti-SRBC responses. Furthermore, the enhancing effect on antibody responses to thymus-independent antigens, such as dinitrophenyl- Ficoll and trinitrophenyl-lipopolysaccharide, was observed neither in nu/nu nor in nu/+ mice, and the effect on delayed-type hypersensitivity response to a low dose of SRBC in normal mice was also found. These findings suggest that the oral immune enhancement by KGF-C is elucidated probably through T-cell but not through B-cell participation.
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Authors | M Murofushi, J Mizuguchi, K Aibara, T Matuhasi |
Journal | Immunopharmacology
(Immunopharmacology)
Vol. 12
Issue 1
Pg. 29-35
(Aug 1986)
ISSN: 0162-3109 [Print] Netherlands |
PMID | 3531087
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- Polysaccharides
- kefir grain polysaccharide
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Topics |
- Adjuvants, Immunologic
- Administration, Oral
- Animals
- Dose-Response Relationship, Drug
- Hemolytic Plaque Technique
- Hypersensitivity, Delayed
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains
- Mice, Nude
- Polysaccharides
(administration & dosage, metabolism, pharmacology)
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