A double-blind trial of fentonium bromide in the treatment of incontinent unstable bladder.

Abstract	The effects of fentonium were compared with those of placebo in a double-blind, cross-over trial involving 28 incontinent women with unstable bladder. Fentonium bromide proved significantly more effective in reducing urgency and urge incontinence (p less than 0.05), in reducing detrusor pressure rise during bladder filling (p less than 0.01) and in increasing bladder volume at first stimulus (p less than 0.05). Well tolerated, fentonium bromide proved useful in the treatment of unstable bladder.
Authors	R Milani, E Merlo, S Scalambrino, R Viganò
Journal	International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 24 Issue 8 Pg. 421-4 (Aug 1986) ISSN: 0174-4879 [Print] Germany
PMID	3531034 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References	Atropine Derivatives Parasympatholytics fentonium
Topics	Adult Aged Atropine Derivatives (therapeutic use) Clinical Trials as Topic Double-Blind Method Female Humans Middle Aged Parasympatholytics (therapeutic use) Urinary Incontinence (drug therapy) Urinary Incontinence, Stress (drug therapy)

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