EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.

Abstract	The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular for the treatment of metastatic neuroendocrine tumours using ligands for somatostatin receptors and prostate adenocarcinoma with small-molecule PSMA-targeting ligands. This paper provides an overview of reported dosimetry data for these therapies and summarises current knowledge about radiation-induced side effects on normal tissues and dose-effect relationships for tumours. Dosimetry methods and data are summarised for kidneys, bone marrow, salivary glands, lacrimal glands, pituitary glands, tumours, and the skin in case of radiopharmaceutical extravasation. Where applicable, taking into account the present status of the field and recent evidence in the literature, guidance is provided. The purpose of these recommendations is to encourage the practice of patient-specific dosimetry in therapy with 177Lu-labelled compounds. The proposed methods should be within the scope of centres offering therapy with 177Lu-labelled ligands for somatostatin receptors or small-molecule PSMA.
Authors	Katarina Sjögreen Gleisner, Nicolas Chouin, Pablo Minguez Gabina, Francesco Cicone, Silvano Gnesin, Caroline Stokke, Mark Konijnenberg, Marta Cremonesi, Frederik A Verburg, Peter Bernhardt, Uta Eberlein, Jonathan Gear
Journal	European journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 49 Issue 6 Pg. 1778-1809 (05 2022) ISSN: 1619-7089 [Electronic] Germany
PMID	35284969 (Publication Type: Journal Article)
Copyright	© 2022. The Author(s).
Chemical References	Ligands Radioisotopes Radiopharmaceuticals Receptors, Somatostatin Somatostatin Lutetium Lutetium-177 Prostate-Specific Antigen
Topics	Humans Ligands Lutetium (therapeutic use) Male Prostate-Specific Antigen Radiation Injuries Radioisotopes Radiopharmaceuticals (adverse effects) Receptors, Somatostatin Somatostatin

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