[The effectiveness of transtympanic use of dexamethasone 4 mg in Meniere's disease, severe and moderate course of the disease].

Abstract

The results of transtympanic administration of 4 mg dexamethasone in 37 patients with moderate and severe Meniere's disease are presented. The endolymphatic hydrops was detected in all inner ear structures with predominant accumulation in vestibule and semicircular canals by MRI-visualization before therapy. After 1 month of 4 mg dexamethasone transtympanic therapy the hydrops degree decreased. Daily transtympanic administration of 4 mg dexamethasone for a month leads to reduction of vertigo attacks duration and expression in 92% of cases (follow-up period 24 months) and can be considered when conservative therapy is ineffective before destructive surgical interventions.

• Authors: A I Kryukov, N L Kunelskaya, E V Garov, E A Stepanova, P A Sudarev, E S Yanyushkina, A S Abramenko, E E Garova, E V Larionova
• Journal: Vestnik otorinolaringologii (Vestn Otorinolaringol) Vol. 87 Issue 1 Pg. 21-26 ( 2022) ISSN: 0042-4668 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' transtimpanal'nogo primeneniya deksametazona 4 mg pri bolezni Men'era, tyazhelom i srednetyazhelom techenii zabolevaniya.
• PMID: 35274888 (Publication Type: Journal Article)

Chemical References

• Dexamethasone

Topics

• Dexamethasone
• Endolymphatic Hydrops
• Humans
• Magnetic Resonance Imaging (methods)
• Meniere Disease (complications, diagnosis, drug therapy)
• Vestibule, Labyrinth