Efficacy of oral mexiletine in the prevention of exercise-induced ventricular ectopic activity.

Abstract

The anti-arrhythmic effect of oral mexiletine on exercise-induced ventricular arrhythmia was studied in a double blind trial of 10 patients suffering from ventricular ectopic beats of different origins. There was a good reproducibility of the amount of ectopic ventricular activity between consecutive exercise tests when no active drug was given. Treatment for 1 week with mexiletine 600 mg daily resulted in a statistically significant reduction in ventricular ectopic beats, particularly during and after exercise; there were virtually no side-effects. The results suggest that mexiletine has considerable potential in the treatment of ventricular arrhythmias.

• Authors: G Koch, B Lindström
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 13 Issue 4 Pg. 237-40 (Jun 19 1978) ISSN: 0031-6970 [Print] Germany
• PMID: 352705 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Propylamines
• Mexiletine

Topics

• Adult
• Aged
• Arrhythmias, Cardiac (etiology, physiopathology, prevention & control)
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Heart Ventricles
• Humans
• Male
• Mexiletine (adverse effects, therapeutic use)
• Middle Aged
• Physical Exertion
• Propylamines (therapeutic use)
• Pulse (drug effects)