Abstract | Background: Methods: We searched PubMed/Medline (1980-2020), Cochrane Library (1980-2020), Cochrane CENTRAL (from establishment to 2020), ClinicalTrials.gov (from establishment to 2020), Chinese Journal Full-text Database (CNKI, 1994-2020), China Biology Medicine disc (CBM, 1978-2019), Chinese Scientific Journal Database (VIP, 1989-2020) and Wanfang Database (WFDATA, 1980-2019). Randomized controlled trials (RCTs), quasi-RCTs and controlled clinical trials treating patients with acute skin wounds from various causes and with those available growth factors were included. Results: A total of 7573 papers were identified through database searching; 229 papers including 281 studies were kept after final screening. Administering growth factors significantly shortened the healing time of acute skin wounds, including superficial burn injuries [mean difference (MD) = -3.02; 95% confidence interval (CI):-3.31 ~ -2.74; p < 0.00001], deep burn injuries (MD = -5.63; 95% CI:-7.10 ~ -4.17; p < 0.00001), traumata and surgical wounds (MD = -4.50; 95% CI:-5.55 ~ -3.44; p < 0.00001). Growth factors increased the healing rate of acute skin wounds and decreased scar scores. The incidence of adverse reactions was lower in the growth factor treatment group than in the non- growth factor group. Conclusions: The studied growth factors not only are effective and safe for managing acute skin wounds, but also accelerate their healing with no severe adverse reactions.
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Authors | Yating Wei, Jiangfeng Li, Yao Huang, Xun Lei, Lijun Zhang, Meifang Yin, Jiawen Deng, Xiaoyan Wang, Xiaobing Fu, Jun Wu |
Journal | Burns & trauma
(Burns Trauma)
Vol. 10
Pg. tkac002
( 2022)
ISSN: 2321-3868 [Print] England |
PMID | 35265723
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2022. Published by Oxford University Press. |