[Correction of proteolysis disturbances and erythrocyte resistance in experimental burns by the antioxidant carbaton].

Abstract

The total proteolytic activity in blood and tissues and peroxide resistance of erythrocytes were studied in animals at different stages of burn disease. Carbaton, an antioxidant of a pyridine series, is analyzed for its effect on these indices. Considerable activation of proteolysis in tissues and a decrease of the erythrocyte resistance at burn shock and septicotoxemia stages are established. Carbaton being applied as a drug, influences positively the studied processes; a degree of the shift correction depends on the preparation dose.

• Authors: G G Shershun, O F Kagan, A A Kiiashko, I N Butvin, L M Rubina
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1986 May-Jun Vol. 58 Issue 3 Pg. 78-80 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Korrektsiia narusheniĭ proteoliza i rezistentnosti éritrotsitov pri éksperimental'noĭ ozhogovoĭ bolezni antioksidantom karbatonom.
• PMID: 3523896 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Free Radicals
• Pyridines
• carbaton
• Endopeptidases

Topics

• Animals
• Antioxidants (pharmacology, therapeutic use)
• Burns (blood, drug therapy, metabolism)
• Endopeptidases (blood, metabolism)
• Free Radicals
• Guinea Pigs
• Hemolysis (drug effects)
• Hydrolysis
• Pyridines (pharmacology, therapeutic use)