Lactobacillus gasseri PA-3 reduces serum uric acid levels in patients with marginal hyperuricemia.

Abstract

Several studies have reported that Lactobacillus gasseri PA-3 reduces the level of serum uric acid (SUA) in patients with hyperuricemia. However, it remains unknown how PA-3 affects uric acid metabolism. In the present study, we examined effects of PA-3-containing yoghurt on uric acid metabolism in patients with marginal hyperuricemia. Sixteen patients with SUA > 357 μmol/L (marginal hyperuricemia) were enrolled. PA-3-containing yoghurt was administered for 8 weeks. Uric acid metabolism was evaluated just before and 8 weeks after the administration and at 4 weeks after the administration ended (post-administration). SUA levels after the administration were significantly lower than that before the administration and remained low at post-administration. Urinary uric acid concentration (Uur) after the administration were significantly lower than that before the administration. However, post-administration Uur levels were comparable to those before the administration. Therefore, PA-3-containing yoghurt significantly reduced the levels of SUA and Uur in patients with marginal hyperuricemia.

• Authors: Toshihiro Hamada, Ichiro Hisatome, Takayuki Wakimizu, Masahiko Kato, Tamotsu Gotou, Atsuro Koga, Yusuke Endo, Shin-Ichi Taniguchi, Kazuhiro Yamamoto, Haruaki Ninomiya, Hiroshi Tsuboi, Makoto Yamaguchi, Naruomi Yamada, Hiroshi Kano, Yukio Asami
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) Vol. 41 Issue 4 Pg. 361-369 ( 2022) ISSN: 1532-2335 [Electronic] United States
• PMID: 35227163 (Publication Type: Journal Article)

Chemical References

• Uric Acid

Topics

• Humans
• Hyperuricemia
• Lactobacillus gasseri (metabolism)
• Uric Acid