Inverse-Designed Aid Lenses for Precise Correction of Color Vision Deficiency.

Abstract

Color vision deficiency (CVD) is a common ocular disorder affecting more than 300 million people on the earth. Although no clinical cure for the disorder currently exists, some specialized color filtering glasses/lenses based on dyes, metasurfaces, or nanocomposites have been employed for CVD management. However, as CVD patients usually diversify in their classification and severity, none of the current lenses provides a customized correction for various CVD patients, resulting in undesirable correction effects. Here, we present an inverse-designed approach for the precise correction of CVD. The wavelength shift of a patient's abnormal cone photoreceptors was measured to inversely design the best blocking wavelength and blocking rate of the lens. Then the customized aid lenses were fabricated using silica-coated gold nanoparticles with appropriate sizes and concentrations, verified by the simulated color vision and human tests. This study demonstrates the potential of the inverse-designed aid lenses in precise color filtering and customized CVD management.

• Authors: Ye Tian, Hanchuan Tang, Tianyu Kang, Xinyi Guo, Jiaxin Wang, Jianfeng Zang
• Journal: Nano letters (Nano Lett) Vol. 22 Issue 5 Pg. 2094-2102 (03 09 2022) ISSN: 1530-6992 [Electronic] United States
• PMID: 35226508 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gold

Topics

• Cardiovascular Diseases
• Color
• Color Vision Defects (therapy)
• Gold
• Humans
• Metal Nanoparticles (therapeutic use)
• Nanocomposites