Platelets for cancer treatment and drug delivery.

Abstract

Extensive research is currently being conducted into a variety of bio-inspired biomimetic nanoparticles (NPs) with new cell simulation functions across the fields of materials science, chemistry, biology, physics, and engineering. Cells such as erythrocytes, platelets, and stem cells have been engineered as new drug carriers. The platelet-derived drug delivery system, which is a new targeted drug delivery system (TDDS), can effectively navigate the blood circulatory system and interact with the complex tumor microenvironment; it appears to outperform traditional anticancer drugs; hence, it has attracted considerable research interest. In this review, we describe innovative studies and outline the latest progress regarding the use of platelets as tumor targeting and drug delivery vehicles; we also highlight opportunities and challenges relevant to the manufacture of tumor-related platelet TDDSs.

• Authors: Gaozhe Xiao, Zhikun Zhang, Qiaoying Chen, Tao Wu, Wei Shi, Lu Gan, Xiuli Liu, Yong Huang, Mengyu Lv, Yongxiang Zhao, Pan Wu, Liping Zhong, Jian He
• Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (Clin Transl Oncol) Vol. 24 Issue 7 Pg. 1231-1237 (Jul 2022) ISSN: 1699-3055 [Electronic] Italy
• PMID: 35218523 (Publication Type: Journal Article, Review)
• Copyright: © 2022. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).

Chemical References

• Drug Carriers

Topics

• Blood Platelets
• Drug Carriers (therapeutic use)
• Drug Delivery Systems
• Humans
• Nanoparticles
• Neoplasms (drug therapy)
• Tumor Microenvironment