Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin in the arteriole of the hamster cheek pouch.

Abstract

Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin (CS-570), a chemically stable prostaglandin I2 (PGI2, epoprostenol, prostacyclin) derivative, were investigated in the arteriole of the hamster cheek pouch. A microthrombus was produced by a slight mechanical injury followed by iontophoretic application of adenosine diphosphate (ADP) to an arteriole of 70 to 100 micron in diameter. The platelet thrombus size was determined with a video image processor. With this technique, a reproducible and quantitatively measurable periodical thrombus was obtained. CS-570 inhibited the thrombus formation dose-dependently. The potency of CS-570 was about 1/8 that of PGI2 and 6 times that of carbacyclin when infused i.v. CS-570 also decomposed an established thrombus. Alprostadil (PGE1), dipyridamole and ticlopidine failed to show inhibitory effects. The antithrombotic effect of CS-570 was definitely demonstrated.

• Authors: A Morita, K Endo, M Mori, K Akiyama, K Kohata, S Kobayashi
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 4 Pg. 676-9 (Apr 1986) ISSN: 0004-4172 [Print] Germany
• PMID: 3521615 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• Thiophenes
• Adenosine Diphosphate
• Dipyridamole
• carboprostacyclin
• R 59274
• Epoprostenol
• Ticlopidine

Topics

• Adenosine Diphosphate (pharmacology)
• Animals
• Arteries (drug effects)
• Cheek (blood supply)
• Cricetinae
• Dipyridamole (pharmacology)
• Epoprostenol (pharmacology)
• Fibrinolytic Agents (pharmacology)
• Male
• Mesocricetus
• Regional Blood Flow (drug effects)
• Thiophenes (pharmacology)
• Ticlopidine
• Time Factors