Abstract |
Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin (CS-570), a chemically stable prostaglandin I2 (PGI2, epoprostenol, prostacyclin) derivative, were investigated in the arteriole of the hamster cheek pouch. A microthrombus was produced by a slight mechanical injury followed by iontophoretic application of adenosine diphosphate ( ADP) to an arteriole of 70 to 100 micron in diameter. The platelet thrombus size was determined with a video image processor. With this technique, a reproducible and quantitatively measurable periodical thrombus was obtained. CS-570 inhibited the thrombus formation dose-dependently. The potency of CS-570 was about 1/8 that of PGI2 and 6 times that of carbacyclin when infused i.v. CS-570 also decomposed an established thrombus. Alprostadil ( PGE1), dipyridamole and ticlopidine failed to show inhibitory effects. The antithrombotic effect of CS-570 was definitely demonstrated.
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Authors | A Morita, K Endo, M Mori, K Akiyama, K Kohata, S Kobayashi |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 36
Issue 4
Pg. 676-9
(Apr 1986)
ISSN: 0004-4172 [Print] Germany |
PMID | 3521615
(Publication Type: Journal Article)
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Chemical References |
- Fibrinolytic Agents
- Thiophenes
- Adenosine Diphosphate
- Dipyridamole
- carboprostacyclin
- R 59274
- Epoprostenol
- Ticlopidine
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Topics |
- Adenosine Diphosphate
(pharmacology)
- Animals
- Arteries
(drug effects)
- Cheek
(blood supply)
- Cricetinae
- Dipyridamole
(pharmacology)
- Epoprostenol
(pharmacology)
- Fibrinolytic Agents
(pharmacology)
- Male
- Mesocricetus
- Regional Blood Flow
(drug effects)
- Thiophenes
(pharmacology)
- Ticlopidine
- Time Factors
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