Abstract |
Preleukemia has generally been treated by palliative measures. Several reports have indicated that cytarabine given as low-dose infusion results in responses, albeit short lived, in a fraction of patients. We have shown recently that marrow transplantation offers a useful alternative. Twelve patients have been treated and followed for a minimum of 1 year. Three were conditioned with cyclophosphamide (CY) only, and all died with recurrent or persistent disease. Nine were conditioned with CY and total-body irradiation; all but 1 had lasting engraftment, and 7 are surviving, free of disease, 16-36 (median 27) months after transplantation. These data show that marrow transplantation can provide successful therapy for preleukemia.
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Authors | H J Deeg |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 76
Issue 6
Pg. 1329-32
(Jun 1986)
ISSN: 0027-8874 [Print] United States |
PMID | 3520076
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Bone Marrow Transplantation
- Child
- Child, Preschool
- Cyclophosphamide
(therapeutic use)
- Female
- Humans
- Male
- Preleukemia
(therapy)
- Transplantation, Homologous
- Whole-Body Irradiation
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