[Effectiveness of nonsteroidal antiphlogistics in experimental diabetes mellitus].

Abstract

In experiments on rats with alloxan diabetes efficacy of amidopyrine, acetylsalicylic acid, methyluracil, butadione and brufen in experimental inflammation was shown. The antiinflammatory drugs under study were found to have various effects on insulin and glucose blood levels in intact rats and those with diabetes. The increase in glucose content under the influence of methyluracil is presumably connected with the elevation of somatotrophic hormone blood level. Acetylsalicylic acid and butadione reduce the content of somatotrophic hormone. Methyluracil potentiates antiexudative effects of acetylsalicylic acid and amidopyrine.

• Authors: Kh M Nasyrov, T V Morugova
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 Mar-Apr Vol. 49 Issue 2 Pg. 75-8 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' nekotorykh nesteroidnykh antiflogistikov pri éksperimental'nom sakharnom diabete.
• PMID: 3519277 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Blood Glucose
• Insulin
• Growth Hormone

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Blood Glucose (analysis)
• Diabetes Mellitus, Experimental (blood, drug therapy)
• Drug Evaluation, Preclinical
• Female
• Granuloma (blood, drug therapy)
• Growth Hormone (blood)
• Insulin (blood)
• Male
• Rats
• Time Factors