Aneuploidy-inducing chemicals in yeast evaluated by the micronucleus test.

Abstract

Chinese hamsters were exposed to acetone, methyl ethyl ketone, ethyl acetate and 2-methoxy ethyl acetate, known to be strong inducers of aneuploidy in the yeast Saccharomyces cerevisiae. All solvents yielded negative results in the micronucleus test, whereas the vinca alkaloid vindesine--used as a positive control substance--proved to act as a spindle poison in mammals in vivo.

• Authors: A Basler
• Journal: Mutation research (Mutat Res) Vol. 174 Issue 1 Pg. 11-3 (May 1986) ISSN: 0027-5107 [Print] Netherlands
• PMID: 3517637 (Publication Type: Journal Article)

Chemical References

• Acetates
• Butanones
• Mutagens
• Solvents
• Acetone
• 2-methoxy ethyl acetate
• methylethyl ketone
• ethyl acetate
• Vindesine

Topics

• Acetates (administration & dosage, analogs & derivatives, pharmacology)
• Acetone (pharmacology)
• Aneuploidy
• Animals
• Butanones (pharmacology)
• Cell Nucleus (ultrastructure)
• Cricetinae
• Female
• Male
• Mutagenicity Tests (methods)
• Mutagens
• Saccharomyces cerevisiae (drug effects, genetics)
• Solvents (pharmacology)
• Vindesine (pharmacology)