Efficacy of cefmenoxime in experimental group B streptococcal bacteraemia and meningitis.

Abstract

Cefmenoxime, a new semisynthetic cephalosporin, was evaluated in vitro and in vivo in comparison with penicillin G against a type III group B streptococcal strain. In vitro, the minimal inhibitory and minimal bactericidal concentrations of the two drugs were very close (less than or equal to 2 dilutions). In-vivo studies using experimental bacteraemia and meningitis in newborn rats revealed that despite similar drug levels, cefmenoxime had significantly greater bactericidal titres in blood at 6-7 h after administration and bacterial clearance from blood was significantly faster with cefmenoxime than with penicillin G at the end of one day of treatment. In addition, all animals with cefmenoxime therapy had bactericidal titres in cerebrospinal fluid greater than or equal to 1:8 at 1-2 h after administration, whereas most (67%) animals receiving penicillin G had titres less than 1:8. However, overall efficacy of cefmenoxime was similar to that of penicillin G. These findings suggest that cefmenoxime may be an effective alternative against group B streptococcal infection.

• Authors: K S Kim
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 17 Issue 2 Pg. 239-44 (Feb 1986) ISSN: 0305-7453 [Print] England
• PMID: 3516964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cefmenoxime
• Cefotaxime
• Penicillin G

Topics

• Animals
• Cefmenoxime
• Cefotaxime (analogs & derivatives, metabolism, therapeutic use)
• Meningitis, Pneumococcal (cerebrospinal fluid, drug therapy)
• Microbial Sensitivity Tests
• Penicillin G (therapeutic use)
• Rats
• Sepsis (drug therapy)
• Streptococcal Infections (drug therapy)
• Streptococcus agalactiae (drug effects)