Nicolau syndrome caused by Glatiramer.

Abstract

Injection-site reactions to glatiramer are common and include erythema, pruritus, pain, or induration. Additionally, the present systematic review of the literature documents 20 cases of Nicolau syndrome following glatiramer, a rare but potentially severe skin reaction. Abdomen and thighs are the most frequently affected areas (80% of reported cases), and permanent skin damage has been observed in 30% of cases. Recurrences are rare (<10%).

• Authors: Sandro Ciprian, Sebastiano A G Lava, Gregorio P Milani, Mario G Bianchetti, Danilo Consolascio, Pietro F Lardelli
• Journal: Multiple sclerosis and related disorders (Mult Scler Relat Disord) Vol. 57 Pg. 103365 (Jan 2022) ISSN: 2211-0356 [Electronic] Netherlands
• PMID: 35158471 (Publication Type: Letter)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Glatiramer Acetate

Topics

• Glatiramer Acetate (adverse effects)
• Humans
• Injections, Intramuscular
• Nicolau Syndrome
• Pain
• Skin