Bornaprine vs placebo in Parkinson disease: double-blind controlled cross-over trial in 30 patients.

Abstract

The study covers 30 patients with idiopathic Parkinson disease, 13 men and 17 women, aged between 50 and 70, on stabilized L-Dopa and/or bromocriptine, which failed to ensure adequate control of the symptoms, especially tremor. To this regimen was added Bornaprine/placebo in randomized sequence. The patients were tested according to the Webster Rating Scale before, during and after each stage of the treatment. Statistical analysis of the results showed the superiority of Bornaprine over the placebo in reducing tremor (p less than 0.01) and, to a lesser degree, some other parkinsonian symptoms. No noteworthy side effects were found apart from dryness of the mouth, which was more frequent with Bornaprine.

• Authors: R Cantello, A Riccio, M Gilli, M Delsedime, L Scarzella, M Aguggia, B Bergamasco
• Journal: Italian journal of neurological sciences (Ital J Neurol Sci) Vol. 7 Issue 1 Pg. 139-43 (Feb 1986) ISSN: 0392-0461 [Print] Italy
• PMID: 3514543 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Bridged-Ring Compounds
• bornaprine

Topics

• Adult
• Aged
• Bridged-Ring Compounds (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Drug Tolerance
• Female
• Humans
• Male
• Middle Aged
• Parkinson Disease (drug therapy)