Positive effects of carbamazepine on behavioral dyscontrol in borderline personality disorder.

Abstract

In a double-blind crossover trial, carbamazepine, an anticonvulsant with primary effects on subcortical limbic structures, decreased the severity of behavioral dyscontrol in 11 women with borderline personality disorder significantly more than placebo. The authors emphasize the preliminary nature of their findings and discuss alternative hypotheses regarding mechanisms by which carbamazepine might influence behavioral dyscontrol.

• Authors: D L Gardner, R W Cowdry
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 143 Issue 4 Pg. 519-22 (Apr 1986) ISSN: 0002-953X [Print] United States
• PMID: 3513634 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Placebos
• Carbamazepine

Topics

• Adult
• Ambulatory Care
• Anger (drug effects)
• Borderline Personality Disorder (drug therapy, physiopathology, psychology)
• Carbamazepine (pharmacology, therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Impulsive Behavior (drug therapy, psychology)
• Limbic System (drug effects, physiopathology)
• Personality Disorders (drug therapy)
• Placebos
• Self Mutilation (drug therapy, psychology)
• Suicide, Attempted (psychology)