Effect of prostacyclin (PGI2) and a prostaglandin analogue BW 245C on galactosamine-induced hepatic necrosis.

Abstract

The reported cytoprotective effects of prostaglandins against noxious stimuli in the liver was the basis for the present investigations of the effects of prostacyclin (PGI2) and a prostaglandin analogue (BW 245C) in an animal model of severe liver failure. Rats were given galactosamine at two dose levels and the prostaglandins were given in repeated doses from 0 to 6 h during the development of the liver damage or in another group from 24 to 30 h at the time of maximal liver injury. For PGI2 significant cytoprotection was found as assessed by a reduction in blood Normotest at 24, 48 and 72 h (P less than 0.05) and the plasma level of aspartate aminotransferase at 24 and 48 h (P less than 0.02) and the lysosomal markers N-acetyl-beta-glucosaminidase at 24, 48 and 72 h (P less than 0.001) and cathepsin D at 48 h (P less than 0.005) as compared to appropriate controls. Early administration of PGI2 reduced the mortality rate from 63% in the control group to 0% (P less than 0.01) in the treated group, but no significant effects were found when either compound was given later in the 24-h to 30-h period.

• Authors: Y Noda, R D Hughes, R Williams
• Journal: Journal of hepatology (J Hepatol) Vol. 2 Issue 1 Pg. 53-64 ( 1986) ISSN: 0168-8278 [Print] Netherlands
• PMID: 3512686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydantoins
• Nucleotides, Cyclic
• Galactosamine
• BW 245C
• Epoprostenol
• Aspartate Aminotransferases
• Acetylglucosaminidase
• Cathepsin D

Topics

• Acetylglucosaminidase (analysis)
• Animals
• Aspartate Aminotransferases (analysis)
• Cathepsin D (analysis)
• Epoprostenol (pharmacology)
• Galactosamine (toxicity)
• Hydantoins (pharmacology)
• Liver (drug effects, pathology)
• Male
• Necrosis
• Nucleotides, Cyclic (analysis)
• Rats
• Rats, Inbred Strains