Abstract |
The new third generation cephalosporins have a significantly greater spectrum of action against gram-negative bacteria likely to be encountered in surgical infections. This expanded spectrum may permit these drugs to be used in place of combination therapy in patients with polymicrobial infections; however, current evidence does not indicate superior results with these agents over earlier generation choices for surgical prophylaxis. The toxicity profile of these drugs warrants close monitoring for serious complications.
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Authors | D E Fry |
Journal | American journal of surgery
(Am J Surg)
Vol. 151
Issue 2
Pg. 306-13
(Feb 1986)
ISSN: 0002-9610 [Print] United States |
PMID | 3511763
(Publication Type: Clinical Trial, Journal Article, Review)
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Chemical References |
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Topics |
- Bacteria
(drug effects)
- Bacterial Infections
(drug therapy)
- Central Nervous System Diseases
(drug therapy)
- Cephalosporins
(adverse effects, metabolism, pharmacology, therapeutic use)
- Chemical Phenomena
- Chemistry
- Cholecystitis
(drug therapy)
- Clinical Trials as Topic
- Cross Infection
(drug therapy)
- Female
- Genital Diseases, Female
(drug therapy)
- Humans
- Premedication
- Surgical Wound Infection
(prevention & control)
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