Effectiveness of Calcitonin Gene-Related Peptide Receptor Antagonists for Migraine Treatment: A Meta-Analysis.

Abstract

INTRODUCTION:

The pathophysiology of migraine has been researched incessantly, and it has been suggested that calcitonin gene-related peptide (CGRP) is associated with migraine attacks. CGRP receptor blockers are attracting attention as potential agents for migraine prevention and treatment of acute episodes. This meta-analysis aimed to assess the effects of available CGRP receptor antagonists, focusing on their therapeutic doses for acute migraine treatment.

METHODS:

We systematically searched MEDLINE and Embase from inception to March 27, 2021, for English-language publications using the keywords "migraine" and "calcitonin gene-related peptide"; the searches were limited to human studies.

RESULTS:

Five studies that focused on examining the effects of CGRP receptor antagonists on acute migraine treatment met the eligibility criteria for this meta-analysis. A pooled analysis demonstrated that CGRP receptor antagonists significantly increased freedom from pain (odds ratio [OR] = 2.066, 95% confidence interval [CI] 1.766-2.418, I2 = 0%) and from bothersome symptoms in general (OR = 1.606, 95% CI = 1.408-1.830, I2 = 0%); reduced the intensity of pain (OR = 1.791, 95% CI = 1.598-2.008, I2 = 0%); and increased freedom from nausea (OR = 1.361, 95% CI = 1.196-1.548, I2 = 0%) compared to a placebo.

CONCLUSIONS:

CGRP receptor antagonists are effective for acute migraine treatment and are expected to be used clinically as emerging therapeutic agents.

• Authors: Kyoungjune Pak, Jiyoung Kim, Gha-Hyun Lee, Jae Wook Cho, Hyun-Woo Kim
• Journal: European neurology (Eur Neurol) Vol. 85 Issue 3 Pg. 195-201 ( 2022) ISSN: 1421-9913 [Electronic] Switzerland
• PMID: 35100579 (Publication Type: Meta-Analysis)
• Copyright: © 2022 S. Karger AG, Basel.

Chemical References

• Calcitonin Gene-Related Peptide Receptor Antagonists
• Calcitonin Gene-Related Peptide

Topics

• Calcitonin Gene-Related Peptide (therapeutic use)
• Calcitonin Gene-Related Peptide Receptor Antagonists (pharmacology, therapeutic use)
• Humans
• Migraine Disorders (drug therapy)
• Pain (drug therapy)