| Abstract | A useful model that combines paracentesis with administration of a leukotactic factor was developed in order to study the effects of topical diclofenac sodium on various aspects of ocular inflammation. The increases in intraocular pressure (IOP) and secondary aqueous humor protein concentration induced in rabbits by anterior chamber paracentesis, as well as leukocyte accumulation in the anterior chamber induced by formyl-methionyl-leucyl-phenylalanine, were significantly reduced by topical application of diclofenac sodium at concentrations of 2 mM (0.064%, w/v) and higher. Lower doses consistently affected only IOP and secondary protein concentrations. A slight paracentesis-induced miosis was refractory to diclofenac sodium. That this potent inhibitor of prostaglandin synthesis can reduce important signs of ocular inflammation is well supported in this model. |
| Authors | J M Rowland, C J Ford, R A Della Puca, W D Cash
(Affiliation: Research Department, CIBA-GEIGY Corporation, Ardsley, New York.)
|
| Journal | Journal of ocular pharmacology
(J Ocul Pharmacol)
Vol. 2
Issue 1
Pg. 23-9
( 1986)
ISSN: 8756-3320 UNITED STATES |
| PMID | 3509726
(Publication Type: Journal Article)
|
| Chemical References |
- Prostaglandins
- Diclofenac
|
| Topics |
- Administration, Topical
- Animals
- Chemotaxis, Leukocyte
(drug effects)
- Diclofenac
(administration & dosage, pharmacology)
- Disease Models, Animal
- Endophthalmitis
(drug therapy)
- Male
- Prostaglandins
(biosynthesis)
- Rabbits
|
