Direct Synthesis of Photosensitizable Bacterial Cellulose as Engineered Living Material for Skin Wound Repair.

Abstract

Living materials based on bacterial cellulose (BC) represent a natural and promising candidate for wound dressing. Both physical adsorption and chemical methods have been applied to BC for realizing antibacterial function. However, effective and long-lasting incorporation of bactericidal moieties to BC remains challenging. Herein, a Komagataeibacter sucrofermentans-based direct synthetic method to fabricate photosensitizer-grafted BC through in situ bacterial metabolism in the presence of TPEPy-modified glucose is explored. The results verify that the direct biosynthesis method is efficient and convenient to endow BC with outstanding fluorescence and light-triggered photodynamic bactericidal activity for skin wound repair. This work presents a new approach to fabricate eco-friendly and active wound dressing with light-controlled bactericidal activity by microbial metabolism. The successful modification of the glucose carbon source of microorganisms also offers insights for biosyntheses of other living materials through microbial metabolism.

• Authors: Xingang Liu, Min Wu, Meng Wang, Qida Hu, Jingjing Liu, Yukun Duan, Bin Liu
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 34 Issue 13 Pg. e2109010 (Apr 2022) ISSN: 1521-4095 [Electronic] Germany
• PMID: 35076119 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley-VCH GmbH.

Chemical References

• Anti-Bacterial Agents
• Cellulose

Topics

• Anti-Bacterial Agents (chemistry, pharmacology)
• Bandages
• Cellulose (chemistry)
• Skin (metabolism)
• Wound Healing