Epigallocatechin 3-gallate (EGCG) possesses various
biological functions, including anti-
cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic component originating from
green tea extract that has exhibited versatile bioactivities in combating several
cancers. This review highlights the pharmacological features of EGCG and its therapeutic implications in
cancer and other
metabolic diseases. It modulates numerous signaling pathways, regulating cells' undesired survival and proliferation, thus imparting strong
tumor chemopreventive and
therapeutic effects. EGCG initiates cell death through the intrinsic pathway and causes inhibition of EGFR, STAT3, and ERK pathways in several
cancers. EGCG alters and inhibits ERK1/2, NF-κB, and Akt-mediated signaling, altering the Bcl-2 family
proteins ratio and activating
caspases in
tumor cells. This review focuses on anti-
cancer,
anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic effects of EGCG. We further highlighted the potential of EGCG in different types of
cancer, emphasizing clinical trials formulations that further improve our understanding of the therapeutic management of
cancer and inflammatory diseases.