HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Risk factors for end-stage renal disease in patients with trauma and stage 3 acute kidney injury.

AbstractABSTRACT:
Research on long-term renal outcomes in patients with acute kidney injury (AKI) and trauma, especially those with traumatic brain injury (TBI), has been limited.In this study, we enrolled patients with stage 3 AKI as per the Kidney Disease Improving Global Outcomes guidelines, who initiated renal replacement therapy (RRT). These patients were divided into 2 groups depending on the presence of TBI. Comparing the baseline characteristics and management strategies of each group, we analyzed whether TBI affects the progression of kidney disease.Between January 1, 2014 and June 30, 2020, 51 patients who initiated RRT due to AKI after trauma were enrolled in this study. TBI was identified in 20 patients, and the clinical conditions were not related to TBI in the remaining 31. The study endpoint was set to determine whether the patients of each group needed RRT persistently at discharge and at the time of recent outpatient clinic. Six (30.0%) out of 20 patients with TBI and 2 (6.5%) out of 31 patients without TBI required conventional hemodialysis, as per the most recent data. No significant within-group differences were found in terms of the baseline characteristics and management strategies. In the logistic regression analysis, TBI was independently associated with disease progression to end-stage renal disease.TBI is a risk factor for end-stage renal disease in patients with trauma and stage 3 AKI who initiate RRT.
AuthorsKyunghak Choi, Min Soo Kim, Min Ae Keum, Seongho Choi, Kyu-Hyouck Kyoung, Jihoon T Kim, Sungjeep Kim, Minsu Noh
JournalMedicine (Medicine (Baltimore)) Vol. 101 Issue 3 Pg. e28581 (Jan 21 2022) ISSN: 1536-5964 [Electronic] United States
PMID35060520 (Publication Type: Journal Article)
CopyrightCopyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
Topics
  • Acute Kidney Injury (etiology, therapy)
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Injuries, Traumatic (complications, epidemiology)
  • Female
  • Humans
  • Kidney Failure, Chronic (complications, epidemiology, therapy)
  • Male
  • Middle Aged
  • Renal Replacement Therapy
  • Retrospective Studies
  • Risk Factors
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: