Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by
erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate
2-methacryloyloxyethyl phosphorylcholine (MPC) and
dimethylaminohexadecyl methacrylate (
DMAHDM) into a high impact
polymethylmethacrylate heat-cured
denture base acrylic resin as a potential treatment for
denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a
protein repellent agent and
DMAHDM as an
antifungal agent to prevent the adherence of Candida albicans to the
denture base material. The dual incorporation of MPC and
DMAHDM reduced C. albicans biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and
DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture
acrylic resin provides the benefit of enhancing C. albicans biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of
denture stomatitis.