Attempted protection of spermatogenesis from single doses of gamma-irradiation in the androgen pretreated rat.

Abstract

Spermatogenic stem-cell survival after gamma-irradiation has been investigated in the adult Wistar rat. Single doses of 4.5 and 9 Gy gamma-rays were administered to the testes of rats who received arachis oil (0.1 ml/100 g body weight) or testosterone enanthate (240 micrograms/100 g body weight) subcutaneously three times weekly for 6 weeks prior to radiation and during the week in which the radiations were given. A mean percentage of regenerating seminiferous tubule cross-sections of 32.45% and 7.26% was found in the testes of androgen-pretreated rats at 8 weeks after 4.5 and 9 Gy, respectively. Similar values (33.4% and 6.2%) were obtained in arachis oil-pretreated controls. We therefore conclude that protection of rat spermatogenesis from single doses of gamma-rays cannot be achieved by androgen pretreatment.

• Authors: O K Schlappack, J I Delic, J R Harwood, J A Stanley
• Journal: Archives of andrology (Arch Androl) Vol. 19 Issue 3 Pg. 269-74 ( 1987) ISSN: 0148-5016 [Print] England
• PMID: 3504137 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Peanut Oil
• Plant Oils
• Testosterone
• testosterone enanthate

Topics

• Animals
• Cell Survival
• Epididymis (radiation effects)
• Gamma Rays
• Male
• Organ Size (radiation effects)
• Peanut Oil
• Plant Oils (pharmacology)
• Rats
• Rats, Inbred Strains
• Seminiferous Tubules (radiation effects)
• Spermatogenesis (radiation effects)
• Stem Cells (radiation effects)
• Testis (radiation effects)
• Testosterone (analogs & derivatives, pharmacology)
• Time Factors