HLA associations in an Arab type 1 diabetic population.

Abstract

We have studied HLA-A, -B, -C, -DR, and -DQ antigen frequencies in 63 Type 1 diabetic Arab patients resident in Kuwait. Both HLA-DR3 (relative risk (RR) = 5.80) and -DR4 (RR = 2.87) showed positive associations with Type I diabetes mellitus in these patients whilst -DR2 (RR 0.16) and -DR5 (RR = 0.15) were negatively associated. The strong positive association with both HLA-DR3 and -DR4 was confirmed in Non-Gulf Arabs (RR = 12.55 and 4.29, respectively) whereas the Gulf Arabs had a significant positive association with HLA-DR3 (RR = 4.41) only. The disease was negatively associated with HLA-DR2 (RR = 0.05) in Gulf Arab patients only and with HLA-DR5 (RR = 0.10) in Non-Gulf Arabs only. HLA-DRw52 and -DRw53 were increased in Non-Gulf Arabs only (RR = 3.14 and 4.63, respectively). In both groups there was strong association with HLA-DQ3 (Gulf, RR = 28.11; Non-Gulf, RR = 6.25). Amongst HLA-A, -B, and -C loci, there was a positive association with HLA-B8 (RR = 19.06).

• Authors: K Behbehani, E R Richens, N Abdella, A K Jayyab, A Shaltout, M Al-Saffar, R Siboo
• Journal: Disease markers (Dis Markers) Vol. 5 Issue 3 Pg. 165-9 (Sep 1987) ISSN: 0278-0240 [Print] United States
• PMID: 3502987 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens
• HLA-DR Antigens

Topics

• Diabetes Mellitus, Type 1 (genetics)
• Ethnicity
• Gene Frequency
• HLA Antigens (genetics)
• HLA-DR Antigens (genetics)
• Histocompatibility Testing
• Humans
• Kuwait