A double blind comparison of guanethidine-and-adrenaline drops with 1% adrenaline alone in chronic simple glaucoma.

Abstract

We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10.67 mmHg, and with adrenaline 1% 6.31 mmHg, 24 hours after the commencement of phasing. The combined drop produced satisfactory control of ocular tension in all cases. These results indicate that a combined drop of guanethidine 3% and adrenaline 0.5% is a promising topical therapy for the control of chronic open-angle glaucoma.

• Authors: K B Mills, A E Ridgway
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 62 Issue 5 Pg. 320-3 (May 1978) ISSN: 0007-1161 [Print] England
• PMID: 350265 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Ophthalmic Solutions
• Epinephrine
• Guanethidine

Topics

• Aged
• Chronic Disease
• Clinical Trials as Topic
• Double-Blind Method
• Drug Combinations
• Epinephrine (administration & dosage, therapeutic use)
• Female
• Glaucoma (drug therapy)
• Guanethidine (administration & dosage, therapeutic use)
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions