Proximal-type epithelioid sarcoma in pubic region expressing L-type amino acid transporter 1: A case report.

Abstract

Proximal-type epithelioid sarcoma is an aggressive malignant soft-tissue neoplasm, a "proximal" variant of epithelioid sarcoma, resistant to multimodal therapy and involved in early tumor-related death. Pertinent treatments are, therefore, continually being explored. A 24-year-old woman with nonmetastatic proximal-type epithelioid sarcoma, originating subcutaneously on the right side of the vulva, underwent surgical resection; the lesion recurred, however, leading to death 3 months after the second surgery. Here described is a case of proximal-type epithelioid sarcoma expressing L-type amino acid transporter 1 (LAT1) that transports essential amino acids and p-borono-L-phenylalanine (BPA)-the chemical compound used in boron neutron capture therapy (BNCT)-and is highly expressed in many malignant tumors. Recently, LAT1 has drawn attention, and relevant treatments have been studied-LAT1 inhibitor and BNCT. LAT1 expression in proximal-type epithelioid sarcoma may lead to cogent treatments for the disease.

• Authors: Shunsuke Yahiro, Takuya Fujimoto, Ikuo Fujita, Toshihiro Takai, Toshiko Sakuma, Tamotsu Sudo, Masayuki Morishita, Shunsaku Takigami, Teruya Kawamoto, Hitomi Hara, Toshihiro Akisue, Ryosuke Kuroda, Takanori Hirose
• Journal: SAGE open medical case reports (SAGE Open Med Case Rep) Vol. 10 Pg. 2050313X211067917 ( 2022) ISSN: 2050-313X [Print] England
• PMID: 35024147 (Publication Type: Case Reports)
• Copyright: © The Author(s) 2022.