Abstract |
Fluorescence-activated cell sorter analysis was used to study the peripheral lymphocyte populations during mercuric chloride (HgCl2)-induced autoimmune nephritis in the Brown Norway (BN) rat. Sequential studies showed a transient loss of T cells from peripheral blood attributable to decreases in the percentage of T-helper cells. In addition, there was a decrease in the percentage of T-cytotoxic/suppressor cells prior to the appearance of circulating anti-GBM antibodies, followed by elevated levels of T-suppressor cells during down-regulation of the response. This method may allow closer inspection of the events linking changes in T-cell populations and induction and termination of an autoimmune response.
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Authors | C Bowman, C Green, L Borysiewicz, C M Lockwood |
Journal | Immunology
(Immunology)
Vol. 61
Issue 4
Pg. 515-20
(Aug 1987)
ISSN: 0019-2805 [Print] England |
PMID | 3502119
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Mercuric Chloride
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Topics |
- Animals
- Autoantibodies
(analysis)
- Autoimmune Diseases
(immunology)
- Basement Membrane
(immunology)
- Female
- Glomerulonephritis
(chemically induced, immunology)
- Kidney Glomerulus
(immunology)
- Leukocyte Count
- Mercuric Chloride
- Rats
- Rats, Inbred BN
- T-Lymphocytes
(classification)
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