Herein we have reported a new magneto-fluorescent
nanogel built on photoluminescent comacromer [PEG-
maleic acid-
glycine], N,N-dimethyl aminoethylmethacrylate and
citrate-capped superparamagnetic iron oxide nanoparticles (SPION). The
nanogel was found to have core-shell morphology (SPION core and PEG shell) with particle size around 80 nm. The cytocompatibility of the synthesized
nanogel was studied using MTT, live/dead assays, and flow cytometry. The cellular uptake of the
nanogel on
cervical cancer cell line Hela evaluated through
Prussian blue staining and fluorescence microscopy has revealed good
cancer cell imaging capability. Magnetic
hyperthermia experiments have shown that the synthesized
nanogel caused the lysis of
cancer cells. The fluorescence bioimaging capability of the
nanogel in the murine model has shown good near IR imaging capability. Overall, the reported results suggest that the magneto-fluorescent
nanogel shows promising future potential for
cancer theranostic applications.