Intravitreal injection of liposome-encapsulated ganciclovir in a rabbit model.

Abstract

The authors determined the intravitreal clearance of liposome-encapsulated ganciclovir. Liposome-encapsulated ganciclovir (84.1 micrograms/0.1 ml) was injected into the vitreous cavity of New Zealand rabbits, which were killed at 24 hours and 7, 14, and 28 days after injection. Total ganciclovir concentrations in the vitreous, up to 28 days, were higher than ID50 (50% inhibitory dose) for different clinical and laboratory strains of viruses belonging to the herpes simplex family.

• Authors: G A Peyman, B Khoobehi, M Tawakol, J A Schulman, H A Mortada, H Alkan, R Fiscella
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 7 Issue 4 Pg. 227-9 ( 1987) ISSN: 0275-004X [Print] United States
• PMID: 3501604 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• Drug Carriers
• Liposomes
• Ganciclovir
• Acyclovir

Topics

• Acyclovir (administration & dosage, analogs & derivatives, pharmacokinetics)
• Animals
• Antiviral Agents (administration & dosage, pharmacokinetics)
• Drug Carriers
• Ganciclovir
• Injections
• Liposomes
• Rabbits
• Vitreous Body (metabolism)