Abstract |
This paper reviews the reported clinical, functional and biochemical abnormalities associated with abnormal fibrinogens. It appears from studies on fibrinogen Detroit that a single amino acid substitution in a critical part of the molecule can lead to major functional abnormalities and clinical consequences of either bleeding or thrombosis. Functional defects observed include: abnormal release of fibrinopeptide A or B or both after incubation with thrombin, abnormal polymerization and abnormal clot stabilization.
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Authors | E E Morse |
Journal | Annals of clinical and laboratory science
(Ann Clin Lab Sci)
1978 May-Jun
Vol. 8
Issue 3
Pg. 234-8
ISSN: 0091-7370 [Print] United States |
PMID | 350125
(Publication Type: Journal Article, Review)
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Chemical References |
- Fibrinopeptide A
- Fibrinopeptide B
- Fibrinogen
|
Topics |
- Adolescent
- Adult
- Afibrinogenemia
(genetics, physiopathology)
- Amino Acid Sequence
- Blood Coagulation
- Child
- Child, Preschool
- Female
- Fibrinogen
(metabolism)
- Fibrinopeptide A
(metabolism)
- Fibrinopeptide B
(metabolism)
- Humans
- Infant
- Male
- Middle Aged
- Pedigree
- Structure-Activity Relationship
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