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The fibrinogenopathies.

Abstract
This paper reviews the reported clinical, functional and biochemical abnormalities associated with abnormal fibrinogens. It appears from studies on fibrinogen Detroit that a single amino acid substitution in a critical part of the molecule can lead to major functional abnormalities and clinical consequences of either bleeding or thrombosis. Functional defects observed include: abnormal release of fibrinopeptide A or B or both after incubation with thrombin, abnormal polymerization and abnormal clot stabilization.
AuthorsE E Morse
JournalAnnals of clinical and laboratory science (Ann Clin Lab Sci) 1978 May-Jun Vol. 8 Issue 3 Pg. 234-8 ISSN: 0091-7370 [Print] United States
PMID350125 (Publication Type: Journal Article, Review)
Chemical References
  • Fibrinopeptide A
  • Fibrinopeptide B
  • Fibrinogen
Topics
  • Adolescent
  • Adult
  • Afibrinogenemia (genetics, physiopathology)
  • Amino Acid Sequence
  • Blood Coagulation
  • Child
  • Child, Preschool
  • Female
  • Fibrinogen (metabolism)
  • Fibrinopeptide A (metabolism)
  • Fibrinopeptide B (metabolism)
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Pedigree
  • Structure-Activity Relationship

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