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Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism.

Abstract
Quite surprisingly, the direct introduction of THP into the brain induces a remarkable shift in voluntary alcohol intake... Even as much as 6 mo later, with no further infusions of THP, the remarkable voluntary selection of alcohol did not abate.
AuthorsR D Myers
JournalAlcoholism, clinical and experimental research (Alcohol Clin Exp Res) Vol. 2 Issue 2 Pg. 145-54 (Apr 1978) ISSN: 0145-6008 [Print] England
PMID350078 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Alkaloids
  • Carbolines
  • Isoquinolines
  • Tetrahydropapaveroline
  • Papaverine
Topics
  • Alcohol Drinking
  • Alcoholism (etiology)
  • Alkaloids (metabolism)
  • Animals
  • Brain (drug effects, metabolism)
  • Carbolines (pharmacology)
  • Disease Models, Animal
  • Humans
  • Injections, Intraventricular
  • Isoquinolines (metabolism)
  • Papaverine (analogs & derivatives)
  • Rats
  • Substance Withdrawal Syndrome
  • Tetrahydropapaveroline (pharmacology)
  • Time Factors

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