Abstract |
Joint inflammations were induced in mice by cloned MT4+ Lyt-2- T cells specific for methylated bovine serum albumin. This was done either by intra-articular or by i.v. administration of the cloned T cells, together with local injection of the antigen. Local rechallenge with methylated bovine serum albumin several weeks after waning of the joint inflammation caused a flare-up reaction. The inflammations were quantified by a 99mTc-uptake method and examined histologically. The arthritis induced by the cloned T cells showed aspects of a delayed type hypersensitivity reaction characterized by an intense infiltrate which resembles the inflammation in the human rheumatoid joint. The data presented show that joint inflammations can be induced by T cells only and that, after waning, reexposition to the original antigen can induce a flare-up reaction. The data suggest a central role of T cells in the induction and the exacerbations observed in rheumatoid arthritis.
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Authors | I S Klasen, R M Ladestein, I G Donselaar, W B van den Berg, R Tees, R Benner |
Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 139
Issue 10
Pg. 3275-80
(Nov 15 1987)
ISSN: 0022-1767 [Print] United States |
PMID | 3500213
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens
- methylated bovine serum albumin
- Serum Albumin, Bovine
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Topics |
- Animals
- Antigens
(immunology)
- Arthritis, Rheumatoid
(immunology, pathology)
- Clone Cells
(immunology, transplantation)
- Disease Models, Animal
- Hypersensitivity, Delayed
(immunology, pathology)
- Immunization, Passive
- Inflammation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Nude
- Serum Albumin, Bovine
(immunology)
- T-Lymphocytes
(immunology, transplantation)
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