Abstract | BACKGROUND AND AIM: METHODS: PubMed, Scopus, Web of Science, and Cochrane Library were systematically searched to identify clinical trials that examined the effect of green coffee bean extract on cardio-metabolic risk factors including serum lipid profiles, glycemic status-related markers, blood pressure, and anthropometric indices. Since the included RCTs were carried out in different settings, random effect models were used to conduct all meta-analyses. RESULTS: Fifteen studies (19 arms) consisting of 637 participants were included. The results indicated that green coffee bean extract significantly reduced levels of total cholesterol (-5.93 mg/dl; 95% CI: -9.21, -2.65; I2: 0%), fasting plasma glucose (-2.21 mg/dl; 95% CI: -3.94, -0.48; I2: 32%), systolic blood pressure (-3.08 mmHg; 95% CI: -4.41, -1.75; I2: 26%), diastolic blood pressure (-2.27 mmHg; 95% CI: -3.82, -0.72; I2: 61%), body weight (-1.24 kg; 95% CI: -1.82, -0.66; I2: 15%), and BMI (-0.55 kg/m2; 95% CI: -0.88, -0.22; I2: 73%). Although the pooled effect size of LDL-C, fasting insulin, and waist circumstance were significant, the results were significantly influenced by individual studies. No significant effect was detected for triglycerides, HDL-C, HbA1C, and HOMA-IR. However, the nonsignificant pooled effect size for triglyceride levels was influenced by one individual study. CONCLUSION:
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Authors | Makan Pourmasoumi, Amir Hadi, Wolfgang Marx, Ameneh Najafgholizadeh, Sukhdeep Kaur, Amirhossein Sahebkar |
Journal | Advances in experimental medicine and biology
(Adv Exp Med Biol)
Vol. 1328
Pg. 323-345
( 2021)
ISSN: 0065-2598 [Print] United States |
PMID | 34981487
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG. |
Chemical References |
- Antioxidants
- Blood Glucose
- Plant Extracts
- Triglycerides
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Topics |
- Antioxidants
- Blood Glucose
- Body Weight
- Cardiovascular Diseases
(epidemiology, prevention & control)
- Coffea
(chemistry)
- Heart Disease Risk Factors
- Humans
- Plant Extracts
(therapeutic use)
- Risk Factors
- Seeds
(chemistry)
- Triglycerides
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