[Extramembranous glomerulopathy in chronic B lymphoid leukemia. 5 years' follow-up].

Abstract

A nephrotic syndrome due to membranous nephropathy and B chronic lymphocytic leukemia were simultaneously discovered in a 52 year old patient. Proteinuria was significantly reduced with chlorambucil therapy and nephrotic syndrome disappeared. Treatment withdrawal for 5 months resulted in a significant lowering of serum albumin level, while blood lymphocyte count increased. These observations indicate a probable causal relationship between the lymphoproliferative disease and the onset of the glomerulopathy which is supported by the efficacy of the chemotherapy on the evolution of the nephrotic syndrome.

• Authors: A Baglin, J Prinseau, R Alterescu, B Franc, D Nochy, A Goguel
• Journal: Annales de medecine interne (Ann Med Interne (Paris)) Vol. 138 Issue 3 Pg. 189-92 ( 1987) ISSN: 0003-410X [Print] France
• Vernacular Title: Glomérulopathie extra-membraneuse au cours d'une leucémie lymphoïde chronique B. Recul de 5 ans.
• PMID: 3497598 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• B-Lymphocytes
• Follow-Up Studies
• Glomerulonephritis (etiology)
• Humans
• Leukemia, Lymphoid (complications, drug therapy)
• Male
• Middle Aged
• Nephrotic Syndrome (etiology)